Naked Singularity in a Modified Gravity Theory

The cosmological constant induced by quantum fluctuation of the graviton on a given background is considered as a tool for building a spectrum of different geometries. In particular, we apply the method to the Schwarzschild background with positive and negative mass parameter. In this way, we put on the same level of comparison the related naked singularity (-M) and the positive mass wormhole. We discuss how to extract information in the context of a f(R) theory. We use the Wheeler-De Witt equation as a basic equation to perform such an analysis regarded as a Sturm-Liouville problem . The application of the same procedure used for the ordinary theory, namely f(R)=R, reveals that to this approximation level, it is not possible to classify the Schwarzschild and its naked partner into a geometry spectrum.Comment: 8 Pages. Contribution given to DICE 2008. To appear in the proceeding

Mediators of leukocyte yctivation play a role in disseminated intravascular coagulation during orthotopic liver transplantation

Leukocytes play an important role in the development of disseminated intravascular coagulation (DIC). In the reperfusion phase of OLT a DIC-like situation has been described and has been held responsible for the high blood loss during this phase. We investigated the role of leukocytes in the pathogenesis of DIC in OLT by measuring the leukocytic mediators released upon activation (cathepsin B, elastase, TNF, neopterin) and the levels of thrombin-antithrombin III (TAT) complexes, seen as markers of prothrombin activation. Arterial blood samples were taken at 10 different time points during and after OLT. Samples were also taken of the perfusate released from the liver graft vein during the flushing procedure before the reperfusion phase. Aprotinin was given as a continuous infusion (0.2-0.4 Mill. KlU/hr) and its plasma levels were determined. Significantly elevated levels of neopterin (15-fold; P<0.01), cathepsin B (440-fold; P<0.01) in the perfusate, as compared with the systemic circulation, as well as their significant increases in the early reperfusion phase suggested that they were released by the graft liver. This was paralleled by elevated levels of elastase (1.3-fold, P<0.05), TNF (1.5-fold, P=NS), and TAT complexes (1.4-fold; P<0.1) in the perfusate. Significant correlations could be identified between the parameters of leukocyte activation and TAT complexes, whereas no correlation was observed between any of the parameters investigated and the aprotinin levels. Our results strongly indicate a release of leukocytic mediators from the graft liver during its reperfusion which seems to be related to the parallely increased prothrombin activation. No correlation could be seen between levels of aprotinin and levels of leukocytic mediators

Hubble parameter reconstruction from a principal component analysis: minimizing the bias

A model-independent reconstruction of the cosmic expansion rate is essential to a robust analysis of cosmological observations. Our goal is to demonstrate that current data are able to provide reasonable constraints on the behavior of the Hubble parameter with redshift, independently of any cosmological model or underlying gravity theory. Using type Ia supernova data, we show that it is possible to analytically calculate the Fisher matrix components in a Hubble parameter analysis without assumptions about the energy content of the Universe. We used a principal component analysis to reconstruct the Hubble parameter as a linear combination of the Fisher matrix eigenvectors (principal components). To suppress the bias introduced by the high redshift behavior of the components, we considered the value of the Hubble parameter at high redshift as a free parameter. We first tested our procedure using a mock sample of type Ia supernova observations, we then applied it to the real data compiled by the Sloan Digital Sky Survey (SDSS) group. In the mock sample analysis, we demonstrate that it is possible to drastically suppress the bias introduced by the high redshift behavior of the principal components. Applying our procedure to the real data, we show that it allows us to determine the behavior of the Hubble parameter with reasonable uncertainty, without introducing any ad-hoc parameterizations. Beyond that, our reconstruction agrees with completely independent measurements of the Hubble parameter obtained from red-envelope galaxies.Comment: Modified to match journal versio

Different aprotinin applications influencing hemostatic chances in orthotopic liver transplantation

The effect of different aprotinin applications on hemmtatic changes and blood product requirements in orthotopic liver transplantation was investigated in a prospective, open, and randomized study. From November 1989 to June 1990, 13 patients received aprotinin as a bolus of 0.5 Mill, kallikrein inac-tivator units (KIU) on three occasions in the course of an OLT, whereas 10 other patients were treated with continuous aprotinin infusion of 0.1-0.4 Mill. KIU/hr. Before and after reperfusion of the graft liver, signs of hyperfibrinolysis, measured by thrombelastography, were significantly lower in the infusion group. Tissue-type plasminogen activator (t-PA) activity increased during the anhepatic phase but to a significantly lesser extent in the infusion group. Blood product requirements during OLT were tendentiously higher in the bolus group but not significantly so. However, the use of packed red blood cells was significantly lower in the postoperative period, whereas there was no significant difference in fresh frozen plasma requirements between the two groups. All 23 patients have survived, and only one woman of each group required retransplantation due to severe host-versus-graft reactions. Furthermore, we investigated the perfusate of the graft liver in both groups and detected signs of a decreased t-PA release in the infusion group. Our results demonstrate an advantage of aprotinin given as continuous infusion over bolus application in OLT

The Rate of Type Ia Supernovae at High Redshift

We derive the rates of Type Ia supernovae (SNIa) over a wide range of redshifts using a complete sample from the IfA Deep Survey. This sample of more than 100 SNIa is the largest set ever collected from a single survey, and therefore uniquely powerful for a detailed supernova rate (SNR) calculation. Measurements of the SNR as a function of cosmological time offer a glimpse into the relationship between the star formation rate (SFR) and Type Ia SNR, and may provide evidence for the progenitor pathway. We observe a progressively increasing Type Ia SNR between redshifts z~0.3-0.8. The Type Ia SNR measurements are consistent with a short time delay (t~1 Gyr) with respect to the SFR, indicating a fairly prompt evolution of SNIa progenitor systems. We derive a best-fit value of SFR/SNR 580 h_70^(-2) M_solar/SNIa for the conversion factor between star formation and SNIa rates, as determined for a delay time of t~1 Gyr between the SFR and the Type Ia SNR. More complete measurements of the Type Ia SNR at z>1 are necessary to conclusively determine the SFR--SNR relationship and constrain SNIa evolutionary pathways.Comment: 37 pages, 9 figures, accepted for publication in Astrophysical Journal. Figures 7-9 correcte

Modified Chaplygin Traversable Wormholes

The modified Chaplygin gas (MCG) is a strong candidate for the unified model of dark matter and dark energy. The equation of state of this modified model is valid from the radiation era to the $\Lambda$CDM model. In early epoch (when $\rho$ was large), dark matter had the dominant role while at later stages (when $\rho$ is small), the MCG model behaves as dark energy. In this work, we have found exact solution of static spherically symmetric Einstein equations describing a wormhole for an inhomogeneous distribution of modified Chaplygin gas. For existence of wormhole solution, there are some restrictions relating the parameters in the equation of state for MCG and the throat radius of the wormhole. Physical properties and characteristics of these modified Chaplygin wormholes are analyzed in details.Comment: 9 pages, 1 figur